Michael Kuhn

This is the homepage of Michael Kuhn (né Müller). I am from Leipzig and/or Dresden and lived in Pasadena, CA, for three years while studying at Caltech. I did my PhD in the lab of Peer Bork at the EMBL Heidelberg, working on integrating protein-chemical interactions with phenotypic data to predict drug targets and to find the molecular basis of side effects.

Since July 2009, I have been working as a post doc in the labs of Andreas Beyer (first Biotec, TU Dresden, now University of Cologne) and Tony Hyman (MPI-CBG). My main topic of research is an evolutionary analysis of the centrosome. My wife, Christiane Kuhn, and I are happy parents of three children.

eMail: michaelmckuhnde

Elsewhere: Twitter, bioCS, a blog, Tumblr, Biology StackExchange

Scientific Interests

How did such a complex organelle like the centrosome evolve? How did functional requirements and components change over time?

I am (still) interested in finding the biomolecular basis of diseases and side effects on the level of protein-protein interactions. Can we pinpoint known side effects to target proteins? Can we benefit from a global view on drug-target interactions?

Underlying tools that I built together with others are: STITCH, SIDER, and MATADOR.

Scientific Vita

An affair with chemistry in high school led me twice to the International Chemistry Olympiad. However, I learned from hands-on experience in organic chemistry labs that I did not want to pursue a wet-lab career. Therefore I decided to study computer science at Caltech, where it was also possible to put an emphasis on biochemistry. Caltech's Summer Undergraduate Research Fellowship (SURF) provided me with the opportunity to work in David Baker's lab in Seattle. During a year-long study term in Dresden, I worked on automatically analyzing single molecule force spectroscopy spectra with Daniel Müller. Later, I worked in Michael Schroeder's lab on protein-protein interfaces, again with SURF funding. I received my PhD (Dr. rer. nat.) from the University of Heidelberg with summa cum laude after research in the lab of Peer Bork at the EMBL in Heidelberg. The topic of my PhD thesis was: "Integrating chemical and protein interactions: From interaction networks to human phenotypes."

Publications

See list below, my Google Scholar and ResearcherID profiles, or try this PubMed search which retrieves most of the listed publications.
30.
Kuhn M, Hyman AA, Beyer A.
Coiled-coil proteins facilitated the functional expansion of the centrosome.
PLoS Comput Biol. 2014 Jun 5;10(6):e1003657
29.
Esner M, Meyenhofer F, Kuhn M, Thomas M, Kalaidzidis Y, Bickle M.
Development of a Kinetic Assay for Late Endosome Movement.
J Biomol Screen. 2014 Feb 20.
28.
Powell S, Forslund K, Szklarczyk D, Trachana K, Roth A, Huerta-Cepas J, Gabaldón T, Rattei T, Creevey C, Kuhn M, Jensen LJ, von Mering C, Bork P.
eggNOG v4.0: nested orthology inference across 3686 organisms.
Nucleic Acids Res. 2014 Jan;42(Database issue):D231-9.
27.
Kuhn M, Szklarczyk D, Pletscher-Frankild S, Blicher TH, von Mering C, Jensen LJ, Bork P.
STITCH 4: integration of protein-chemical interactions with user data.
Nucleic Acids Res. 2014 Jan;42(Database issue):D401-7.
26.
Kuhn M, Al Banchaabouchi M, Campillos M, Jensen LJ, Gross C, Gavin AC, Bork P.
Systematic identification of proteins that elicit drug side effects.
Mol Syst Biol. 2013 Apr 30;9:663.
25.
Iskar M, Zeller G, Blattmann P, Campillos M, Kuhn M, Kaminska KH, Runz H, Gavin AC, Pepperkok R, van Noort V, Bork P.
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding.
Mol Syst Biol. 2013 Apr 30;9:662
24.
Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C, Jensen LJ.
STRING v9.1: protein-protein interaction networks, with increased coverage and integration.
Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15.
23.
Zhao XM, Iskar M, Zeller G, Kuhn M, van Noort V, Bork P.
Prediction of drug combinations by integrating molecular and pharmacological data.
PLoS Comput Biol. 2011 Dec;7(12):e1002323.
22.
Powell S, Szklarczyk D, Trachana K, Roth A, Kuhn M, Muller J, Arnold R, Rattei T, Letunic I, Doerks T, Jensen LJ, von Mering C, Bork P.
eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges.
Nucleic Acids Res. 2012 Jan;40(Database issue):D284-9.
21.
Kuhn M*, Szklarczyk D*, Franceschini A, von Mering C, Jensen LJ, Bork P.
STITCH 3: zooming in on protein-chemical interactions.
Nucleic Acids Res. 2012 Jan;40(Database issue):D876-80.
20.
Gallego O, Betts MJ, Gvozdenovic-Jeremic J, Maeda K, Matetzki C, Aguilar-Gurrieri C, Beltran-Alvarez P, Bonn S, Fernández-Tornero C, Jensen LJ, Kuhn M, Trott J, Rybin V, Müller CW, Bork P, Kaksonen M, Russell RB, Gavin AC.
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
Mol Syst Biol. 2010 Nov 30;6:430.
19.
Szklarczyk D*, Franceschini A*, Kuhn M*, Simonovic M, Roth A, Minguez P, Doerks T, Stark M, Muller J, Bork P, Jensen LJ, von Mering C.
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored.
Nucleic Acids Res. 2011 Jan;39(Database issue):D561-8.
18.
Iskar M, Campillos M, Kuhn M, Jensen LJ, van Noort V, Bork P.
Drug-Induced Regulation of Target Expression.
PLoS Comput Biol. 2010 Sep 9;6(9). pii: e1000925.
17.
Katayama T et al.
The DBCLS BioHackathon: standardization and interoperability for bioinformatics web services and workflows
Journal of Biomedical Semantics 2010, 1:8
16.
O'Donoghue SI, Horn H, Pafilis E, Haag S, Kuhn M, Satagopam VP, Schneider R, Jensen LJ.
Reflect: A practical approach to web semantics
Web Semantics: Science, Services and Agents on the World Wide Web, Volume 8, Issues 2-3, July 2010, Pages 182-189
iii.
Lister AL, Datta RS, Hofmann O, Krause R, Kuhn M, Roth B, Schneider R.
Live coverage of scientific conferences using web technologies.
PLoS Comput Biol. 2010 Jan 29;6(1):e1000563.
ii.
Lister AL, Datta RS, Hofmann O, Krause R, Kuhn M, Roth B, Schneider R.
Live Coverage of Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB) 2009.
PLoS Comput Biol. 2010 Jan 29;6(1):e1000640.
15.
Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P.
A side effect resource to capture phenotypic effects of drugs.
Mol Syst Biol. 2010;6:343.
14.
Muller J, Szklarczyk D, Julien P, Letunic I, Roth A, Kuhn M, Powell S, von Mering C, Doerks T, Jensen LJ, Bork P.
eggNOG v2.0: extending the evolutionary genealogy of genes with enhanced non-supervised orthologous groups, species and functional annotations.
Nucleic Acids Res. 2010 Jan;38(Database issue):D190-5.
13.
Kuhn M, Szklarczyk D, Franceschini A, Campillos M, von Mering C, Jensen LJ, Beyer A, Bork P.
STITCH 2: an interaction network database for small molecules and proteins.
Nucleic Acids Res. 2010 Jan;38(Database issue):D552-6.
12.
Pafilis E, O'Donoghue SI, Jensen LJ, Horn H, Kuhn M, Brown NP, Schneider R.
Reflect: augmented browsing for the life scientist.
Nat Biotechnol. 2009 Jun;27(6):508-10.
11.
Pavlopoulos GA, Pafilis E, Kuhn M, Hooper SD, Schneider R.
OnTheFly: a tool for automated document-based text annotation, data linking and network generation.
Bioinformatics. 2009 Apr 1;25(7):977-8.
i.
Saunders N, Beltrão P, Jensen LJ, Jurczak D, Krause R, Kuhn M, Wu S.
Microblogging the ISMB: A New Approach to Conference Reporting.
PLoS Comput Biol. 2009 Jan;5(1):e1000263.
10.
Jensen LJ*, Kuhn M*, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, Bork P, Mering CV.
STRING 8—a global view on proteins and their functional interactions in 630 organisms.
Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6.
9.
Campillos M*, Kuhn M*, Gavin AC, Jensen LJ, Bork P.
Drug target identification using side-effect similarity.
Science. 2008 Jul 11;321(5886):263-6.
8.
Kuhn M*, Campillos M*, González P*, Jensen LJ*, Bork P*.
Large-scale prediction of drug-target relationships.
FEBS Lett. 2008 Apr 9;582(8):1283-90.
7.
Kuhn M, von Mering C, Campillos M, Jensen LJ, Bork P.
STITCH: interaction networks of chemicals and proteins.
Nucleic Acids Res. 2008 Jan;36(Database issue):D684-8.
6.
Günther S, Kuhn M, Dunkel M, Campillos M, Senger C, Petsalaki E, Ahmed J, Urdiales EG, Gewiess A, Jensen LJ, Schneider R, Skoblo R, Russell RB, Bourne PE, Bork P, Preissner R.
SuperTarget and Matador: resources for exploring drug-target relationships.
Nucleic Acids Res. 2008 Jan;36(Database issue):D919-22.
5.
Jensen LJ*, Julien P*, Kuhn M, von Mering C, Muller J, Doerks T, Bork P.
eggNOG: automated construction and annotation of orthologous groups of genes.
Nucleic Acids Res. 2008 Jan;36(Database issue):D250-4.
4.
von Mering C*, Jensen LJ*, Kuhn M, Chaffron S, Doerks T, Kruger B, Snel B, Bork P.
STRING 7--recent developments in the integration and prediction of protein interactions.
Nucleic Acids Res. 2007 Jan;35(Database issue):D358-62.
3.
Kuhn M, Janovjak H, Hubain M, Muller DJ.
Automated alignment and pattern recognition of single-molecule force spectroscopy data.
J Microsc. 2005 May;218(Pt 2):125-32.
2.
Kuhn M, Meiler J, Baker D.
Strand-loop-strand motifs: prediction of hairpins and diverging turns in proteins.
Proteins. 2004 Feb 1;54(2):282-8.
1.
Meiler J, Müller M, Zeidler A, Schmäschke F
Generation and evaluation of dimension-reduced amino acid parameter representations by artificial neural networks.
J. Mol. Model. 7 (2001), 360-369

* - These authors contributed equally. Arabic numerals: peer reviewed papers. Roman numerals: meeting reports etc.

Presentations

Chemicals in Context: from SuperTarget and Matador to STITCH
European Bioinformatics Institute, Hinxton (UK), February 4, 2008
Keynote (zipped), pdf handout, STITCH ScreenCast, SuperTarget ScreenCast, license for all parts: Creative Commons License

Exploring proteins, chemicals and their interactions with STRING and STITCH
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden (Germany), December 18, 2007
Keynote (zipped) Creative Commons License

The STRING database
Exploring Modular Protein Architecture
ENSEIRB, Bordeaux (France), June 15, 2007
ppt Creative Commons License

Tags: simply organize and share links and references with keywords
Novel concepts and easy-to-use web tools for biologists
EMBL Heidelberg, May 30, 2006
ppt Creative Commons License, pdf, video